Mean AVDSF over the first 7 days of PARDS correlated with PIM 2 ( R 2 = 0.10 p = 0.010) and PELOD ( R 2 = 0.12 p = 0.004) scores. Daily AVDSF correlated with daily OI ( R 2 = 0.10 p < 0.001). Results: Sixty-nine PARDS patients with a median (interquartile range) age of 4.5 (0.8, 10.6) years were included in this analysis. Secondary outcomes included 28-day ventilator-free (VFD) and intensive care unit-free (IFD) days. The primary outcome, mortality in PARDS patients, was compared between the high and low AVDSF groups and analyzed in a multivariable logistic regression adjusting for inotrope use and PIM 2 score. Correlation between AVDSF and clinical indices of severity were determined. Receiver operating curve and Youden index were used to identify an AVDSF cutoff associated with mortality, which characterized “high or low AVDSF” groups. AVDSF was calculated by the equation: AVDSF = /P aCO 2. Methods: This was a prospective cohort study performed in the setting of a lung protective mechanical ventilation protocol. This study aims to characterize AVDSF in patients with pediatric ARDS (PARDS), to determine its association with clinical outcomes and examine the validity of a previously studied cutoff (AVDSF > 0.25).
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